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    SmartScience Dx

    • Cordola Hsu AR, Fan W, Harrington D, Wong ND. Acute coronary syndromes in diabetes: Biomarkers of endothelial injury improve risk stratification and help identify predictors of risk. Diabetes METAB Syndr. 2022;16(4):102476.
    • Premyodhin N, Fan W, Younus M, Harrington DS, Wong ND. Novel biomarker panel measuring endothelial injury identifies patients at risk of coronary artery syndrome and discordance with low-density lipoprotein cholesterol. Coron Artery Dis. 2022;31(1):e51-e58.
    • Younus M, Fan W, Harrington DS, Wong ND. Usefulness of a Coronary Artery Disease Predictive Algorithm to Predict Global Risk for Cardiovascular Disease and Acute Coronary Syndrome. Am J Cardiol. 2019;123(5):769-775.

    SmartVascular Dx

    • Kolte D, Libby P, Jang IK. (2021) New Insights Into Plaque Erosion as a Mechanism of Acute Coronary Syndromes. JAMA 325(11):1043-1044
    • Ford TJ, Yii E, Sidik N, et al. (2019) Ischemia and No Obstructive Coronary Artery Disease: Prevalence and Correlates of Coronary Vasomotion Disorders. Circ Cardiovasc Interv 12(12):e008126
    • Galal H, Rashid T, Alghonaimy W, et al. (2019) Detection of positively remodeled coronary artery lesions by multislice CT and its impact on cardiovascular future events. Egypt Heart J 71(1):26
    • Marfella R, Sardu C, Calabro P, et al. (2018) Non-ST-elevation myocardial infarction outcomes in patients with type 2 diabetes with non-obstructive coronary artery stenosis: Effects of incretin treatment. Diabetes Obes Metab 20(3):723-729
    • McCarthy CP, Vaduganathan M, Januzzi JL. (2018) Type 2 Myocardial Infarction-Diagnosis, Prognosis, and Treatment. JAMA 320(5):433-434.
    • The SCOT-HEART Investigators, Newby DE, Adamson PD. (2018) Coronary CT Angiography and 5-Year Risk of Myocardial Infarction. N Engl J Med 379(10):924-933
    • Anderson JL, Morrow DA. (2017) Acute Myocardial Infarction. N Engl J Med 376(21):2053-2064
    • Bally M, Nednukuri N, Rich B, et al. (2017) Risk of acute myocardial Infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data. BMJ May 9;357:j1909
    • Carr JJ, Jacobs DR Jr, Terry JG, et al. (2017) Association of Coronary Artery Calcium in Adults Aged 32 to 46 Years With Incident Coronary Heart Disease and Death. JAMA Cardiol 2(4):391-399
    • Greenslade JH, Nayer R, Parsonage W, et al. (2017) Validating the Manchester Acute Coronary Syndromes (MACS) and Troponin-only Manchester Acute Coronary Syndromes (T-MACS) rules for the prediction of acute myocardial infarction in patients presenting to the emergency department with chest pain. Emerg Med J 34(8):517-523.
    • Keaney JF Jr. (2017) CHIP-ping Away at Atherosclerosis. N Engl J Med 377(2):184-185
    • Lyon J. (2017) More Treatments on Deck for Alcohol Use Disorder. JAMA 317(22):2267-2269
    • Smedegaard L, Nume AK, Charlot M, et al. (2017) Return to Work and Risk of Subsequent Detachment From Employment After Myocardial Infarction: Insights From Danish Nationwide Registries. J Am Heart Assoc 6(10):e006486
    • Smyth A, O’Donnell MO, Yusuf S, et al. (2017) Response by Smyth et al to Letter Regarding Article, “Physical Activity and Anger or Emotional Upset as Triggers of Acute Myocardial Infarction: The INTERHEART Study”. Circulation 135(10):e644-e645
    • Wang EY, Dixson J, Schiller NB, et al. (2017) Causes and Predictors of Death in Patients With Coronary Heart Disease (from the Heart and Soul Study). Am J Cardiol 119(1):27-34
    • Eisen A, Giugliano RP, Braunwald E. (2016) Updates on Acute Coronary Syndrome: A Review. JAMA Cardiol 1(6):718-30
    • Greenwood JP, Ripley DP, Berry C, et al. (2016) Effect of Care Guided by Cardiovascular Magnetic Resonance, Myocardial Perfusion Scintigraphy, or NICE Guidelines on Subsequent Unnecessary Angiography Rates: The CE-MARC 2 Randomized Clinical Trial. JAMA 316(10):1051-60
    • Hess PL, Wojdyla DM, Al-Khatib SM, et al. (2016) Sudden Cardiac Death After Non–ST-Segment Elevation Acute Coronary Syndrome. JAMA Cardiol 1(1):73-79
    • Tisminetzky M, Gurwitz J, Chen HY, et al. (2016) Identification and Characteristics of Low-Risk Survivors of an Acute Myocardial Infarction. Am J Cardiol 117(10):1552-1557
    • Zhang ZM, Rautaharju PM, Prineas RJ, et al. (2016) Race and Sex Differences in the Incidence and Prognostic Significance of Silent Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study. Circulation 133(22):2141-8
    • Crea F. (2015) Coronary microvascular obstruction–a puzzle with many pieces. N Engl J Med 372(15):1464-5
    • Fanaroff AC, Rymer JA, Goldstein SA, et al. (2015) Does This Patient With Chest Pain Have Acute Coronary Syndrome?: The Rational Clinical Examination Systematic Review JAMA (18):1955-655
    • Freedman SB and Lowres N. (2015) Asymptomatic Atrial Fibrillation: The Case for Screening to Prevent Stroke. JAMA 314(18):1911-2
    • Turkbey EB, Nacif MS, Guo M, et al. (2015) Prevalence and Correlates of Myocardial Scar in a US Cohort. JAMA 314(18):1945-1954
    • Zafari AM, Reddy SV, Jeroudi AM, et al. (2015) Myocardial Infarction. Medscape, Sept 15
    • Crea F and Liuzzo G. (2013) Pathogenesis of Acute Coronary Syndromes. J Am Coll Cardiol 61(1):1-11
    • Maddox TM, Stanislawski MA, Grunwald GK, et al. (2014) Nonobstructive coronary artery disease and risk of myocardial infarction. JAMA 312(17):1754-63
    • Abed HS, Wittert GA, Leong DP, et al. (2013) Effect of weight reduction and cardiometabolic risk factor management on symptom burden and severity in patients with atrial fibrillation: a randomized clinical trial. JAMA 310(19):2050-60
    • Mehta D, Thompson R, Morton T. (2013) Innovations iterative model reconstruction: simultaneously lowered computed tomography radiation dose and improved image quality. Med Physics Intl Jrnl 147-155
    • Yeh JS, Lin FY, Kao YT, et al. (2013). Diagnostic Value of Coronary Artery Plaque Detected on Computed Tomography Coronary Angiography in Healthy Adults with Zero to Low Coronary Calcium Scores. J Exp Clin Med (Taiwan) 5(6):222-226
    • Min JK, Berman DS, Dunning A, et al. (2012) All-cause mortality benefit of coronary revascularization vs. medical therapy in patients without known coronary artery disease undergoing coronary computed tomographic angiography: results from CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry. Eur Heart J 33(24):3088-97
    • Youssef G and Budoff MJ. (2012) Coronary artery calcium scoring, what is answered and what questions remain. Cardiovasc Diagn Ther 2(2):94-105
    • Shah PB. (2011) Management of coronary chronic total occlusion. Circulation 123(16): 1780-4
    • Balady GJ, Arena R, Sietsema K, et al. (2010) Clinician’s Guide to cardiopulmonary exercise gesting in adults: a scientific statement from the American Heart Association. Circulation 122(2):191-225
    • Yeh, RW, Sidney S, Chandra M, et al. (2010) Population trends in the incidence and outcomes of acute myocardial infarction. N Engl J Med 362(23):2155-65
    • Chaudhry S, Arena R, Wasserman K, et al. (2009) Exercise-induced myocardial ischemia detected by cardiopulmonary exercise testing. Am J Cardiol 103(5):615-9
    • Dracup K. (2009) The challenge of reducing prehospital delay in patients with acute coronary syndrome. Circ Cardiovasc Qual Outcomes 2(3):144-5
    • Huang H, Mai W, Liu D, et al. (2008) The oxidation ratio of LDL: a predictor for coronary artery disease. Di Markers 24(6):341-9
    • Vítek L, Jirsa M, Brodanova M, et al. (2002) Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis 160(2):449-56
    • Falk E, Shah PK, Fuster V. (1995) Coronary plaque disruption. Circulation 92(3):657-71

    SmartPath Dx*

    • Guo J, Artur C, Womack T, et al. (2019) Multiplex protein-specific microscopy with ultraviolet surface excitation. Biomed Opt Express 11(1):99-108

    SmartLung Dx*

    • Huo J, Xu Y, Sheu T, et al. (2019) Complication Rates and Downstream Medical Costs Associated With Invasive Diagnostic Procedures for Lung Abnormalities in the Community Setting. JAMA Intern Med 179(3):324-332
    • Woodard GA, Wang SX, Kratz JR, et al. (2018) Adjuvant Chemotherapy Guided by Molecular Profiling and Improved Outcomes in Early Stage, Non-Small-Cell Lung Cancer. Clin Lung Cancer 19(1):58-64
    • Lokhandwala T, Bittoni MA, Dann RA, et al. (2017) Costs of Diagnostic Assessment for Lung Cancer: A Medicare Claims Analysis. Clin Lung Cancer 18(1):e27-e34
    • Gould MK, Tang T, Liu IA, et al. (2015) Recent Trends in the Identification of Incidental Pulmonary Nodules. Am J Respir Crit Care Med 192(10):1208-14
    • Meza R, Meernik C, Jeon J, et al. (2015) Lung cancer incidence trends by gender, race and histology in the United States, 1973-2010. PLoS One 10(3):e0121323
    • Kratz JR, He J, Van Den Eeden SK, et al. (2012) A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet 379(9818):823-32
    • National Lung Screening Trial Research Team, et al. (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365(5):395-409
    • Gould MK, Ananth L, Barnett PG, et al. (2007) A clinical model to estimate the pretest probability of lung cancer in patients with solitary pulmonary nodules. Chest 131(2):383-8
    • Evans C, Evans M, Pollock AV. (1974) The incidence and causes of postoperative jaundice. A prospective study. Br J Anaesth 46(7):520-5

    SmartKidney Dx*

    • von Roemeling CA, Caulfield TR, Marlow L, et al. (2017) Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy. Oncotarget 9(1):3-20
    • Neely BA, Wilkins CE, Marlow LA, et al. (2016) Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma. PLoS One 11(4):e0154074
    • von Roemeling CA, Radisky D, Marlow LA, et al. (2014) Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. Cancer Res 74(17):4796-810
    • Leung J and Kim WY. (2013) Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress. Clin Cancer Res 19(12):3111-3
    • von Roemeling CA, Marlow LA, Kennedy WP, et al. (2013) Preclinical evaluation of the mTOR inhibitor, temsirolimus, in combination with the epothilone B analog, ixabepilone in renal cell carcinoma. Am J Cancer Res 3(4):390-401
    • von Roemeling CA, Marlow LA, Wei JJ, et al. (2013) Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res 19(9): 236-80
    • Cooper SJ, Tun HW, Roper SM, et al. (2012) Current Status of Biomarker Discovery in Human clear Cell Renal Cell Carcinoma. J Mol Biomark Diagn S2:005
    • Cooper SJ, von Roemeling CA, Kang KH, et al. (2012) Reexpression of tumor suppressor, sFRP1, leads to antitumor synergy of combined HDAC and methyltransferase inhibitors in chemoresistant cancers. Mol Cancer Ther 11(10):2105-15
    • Tun HW, Marlow LA, con Roemeling CA, et al. (2010) Pathway signature and cellular differentiation in clear cell renal cell carcinoma. PloS One 5(5):e10696
    • Gumz ML, Zou H, Kreinest PA, et al. (2007) Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma. Clin Cancer Res 13(16):4740-9

    Expanded Lipid Profile (ELP)

    • Burgess S, Ference BA, Staley JR, et al. (2018) Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis. JAMA Cardiol 3(7):619-627
    • Navarese EP, Robinson JG, Kowalewski M, et al. (2018) Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis. JAMA 319(15):1566-1579
    • Ravnskov U, Diamond DM, Hama R, et al. (2016) Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review. BMJ Open 6(6):e010401
    • Silverman MG, Ference BA, Im K, et al. (2016) Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis. JAMA 316(12):1289-97
    • Khetarpal SA and Rader DJ. (2015) Triglyceride-rich lipoproteins and coronary artery disease risk: new insights from human genetics. Arterioscler Thromb Vasc Biol 35(2):e3-9
    • Mozaffarian D and Ludwig DS. (2015) Dietary Cholesterol and Blood Cholesterol Concentrations-Reply. JAMA 314(19):2084-5
    • Srisawasdi P, Chaloeysup S, Teerajetgul Y, et al. (2011) Estimation of plasma small dense LDL cholesterol from classic lipid measures. Am J Clin Pathol 136(1):20-9
    • Sniderman A, Williams K, de Graaf J. (2010) Non-HDL C equals apolipoprotein B: except when it does not!. Curr Opin Lipidol 21(6):518-24
    • Harper CR and Jacobson TA. (2010) Using apolipoprotein B to manage dyslipidemic patients: time for a change? Mayo Clin Proc 85(5):440-5
    • Liu J, Sempos CT, Donahue RP, et al. (2006) Non-high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease. Am J Cardiol 98(10):1363-8
    • Walldius G, Jungner I. (2006) The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy–a review of the evidence. J Intern Med 259(5):493-519